One of the ultimate goals of molecular biology is to watch how single proteins work in their native state. The current mainstream approach of single molecule fluorescence relies on introducing external fluorescent markers which can lead to severe issues affecting the experimental results. As an alternative to fluorescence labelling, working in the

We are opening a position for postdoctoral fellowship: experimental nanophotonics and plasmonic nano-optical tweezers. Read the details and apply through the CNRS institutional website: https://bit.ly/3HiobDC Position filled and no longer available. Contact Jerome Wenger for enquiries.

Proteins can feature ultrafast structural dynamics in the nanosecond timescale which are very challenging to measure using conventional techniques such as single-molecule Förster resonance energy transfer (smFRET). So far, the limited fluorescence brightness and the relatively long fluorescence lifetimes have limited the temporal resolution of smF

Back into direct physical format, Jerome will participate to the next "Nuit Européenne des Chercheurs" at Aix en Provence on Sept. 24th. More details and program here.

Important Dates: • R egu lar submission deadline: September 6 , 20 2 2 • Reg ular registration deadline: October 4 , 20 2 2 • Conference: Oc t 25 - 2 7 , 20 2 2

G-quadruplex structures of DNA are promising target sites for anticancer therapy. However, the interaction of G-quadruplex with proteins remains poorly understood, notably the association and dissociation kinetics. In a recent Nucleic Acid Research publication entitled “Fast interaction dynamics of G-quadruplex and RGG-rich peptides unveiled in z

Within the Marie Skłodowska-Curie Doctoral Networks DYNAMO merging of 6 world-leading academic groups and 1 high tech company, we are offering one full PhD fellowship on plasmonic trapping and enhanced UV label-free single protein detection with plasmonic nanopores. See the complete details in the description enclosed below. The application websit

Jerome will give an invited talk at the Biophysical Society Meeting next week. For those unable to join or for those just curious about it, here is a copy of the presentation slides about using metal nanoapertures to improve single molecule fluorescence detection. - BPSmeeting_Wenger_Feb22_export.pdf

Plasmonics can be used to enhance the emission properties of single quantum nano-objects and use them as bright ultrafast single photon sources. However, plasmonic trapping single quantum objects has remained highly challenging so far. In a recent Nano Letters publication, we introduce a dedicated plasmonic nanoantenna design to trap single colloid

Ultraviolet plasmonics has attracted recently a growing attention owing to the possibility to take advantage of increased light-matter interaction in the UV range. However, the core question of demonstrating the capacity of UV plasmonic structures to enhance the radiative emission rate of proteins has remained unproven yet. In a recent article publ